4887-80-3, name is 5-Methoxy-1H-benzo[d]imidazole, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 4887-80-3
General procedure: An excess of 5-substituted benzoimidazoles 4a-d (1.5 equiv.) were dissolved in 8 mL of anhydrous acetonitrile and 1.7 equiv. NaH 95% were added portionwise under stirring in a Schlenk tube at room temperature, applying mechanical vacuum until complete evolution of hydrogen gas. After 15 minutes, 1 g (7.14 mmol) of the 4-hydroxy-2-cyclopentenone acetate (¡À)-1 was dissolved in the minimum amount of anhydrous acetonitrile and added to the solution under stirring. The reactions are left under stirring at room temperature overnight. The reactions were quenched with ice mixed with NaCl/NH4Cl 1:3 and the water phase extracted with DCM. The organic phases were dried over Na2SO4 and, upon evaporation of the solvent, the residues were submitted to chromatographic separation to isolate the purified products 5/6a-d
Statistics shows that 4887-80-3 is playing an increasingly important role. we look forward to future research findings about 5-Methoxy-1H-benzo[d]imidazole.
Reference:
Article; Hameed, Karzan Khaleel; Dezaye, Ahmed Anwar; Hussain, Faiq Hamasaid; Basile, Teresa; Memeo, Misal Giuseppe; Quadrelli, Paolo; Arkivoc; vol. 2018; 7; (2018); p. 201 – 213;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem