Related Products of 716-79-0, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 716-79-0, Name is 2-Phenyl-1H-benzo[d]imidazole, SMILES is C1(C2=CC=CC=C2)=NC3=CC=CC=C3N1, belongs to imidazoles-derivatives compound. In a article, author is Kondaparla, Srinivasarao, introduce new discover of the category.
Design, synthesis and antiplasmodial activity of novel imidazole derivatives based on 7-chloro-4-aminoquinoline
A series of short chain 4-aminoquinoline-imidazole derivatives have been synthesized in one pot two step multicomponent reaction using van leusen standard protocol. The diethylamine function of chloroquine is replaced by substituted imidazole derivatives containing tertiary terminal nitrogen. All the synthesized compounds were screened against the chloroquine sensitive (3D7) and chloroquine resistant (K1) strains of Plasmodium falciparum. Some of the compounds (6, 8, 9 and 17) in the series exhibited comparable activity to CQ against K1 strain of P. falciparum. All the compounds displayed resistance factor between 0.09 and 4.57 as against 51 for CQ. Further, these analogues were found to form a strong complex with hematin and inhibit the beta-hematin formation, therefore these compounds act via heme polymerization target.
Related Products of 716-79-0, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 716-79-0 is helpful to your research.