Application of 693-98-1, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 693-98-1, Name is 2-Methyl-1H-imidazole, SMILES is CC1=NC=CN1, belongs to imidazoles-derivatives compound. In a article, author is Morin, N, introduce new discover of the category.
HPLC retention and inclusion of imidazole derivatives using hydroxypropyl-beta-cyclodextrin as a mobile phase additive
Using the results of high performance liquid chromatography (HPLC), this paper investigates the separation and inclusion of a series of weakly polar imidazole derivatives, with hydroxypropyl-beta-cyclodextrin (HP-beta-CD) in the mobile phase over a wide range of column temperatures. These compounds are used for the treatment of onychomycosis. Gibbs Helmholtz parameters (Delta(Delta H) and Delta(Delta S)) of two adjacent imidazole peak on a chromatogram were determined from the graph of the logarithm of the separation factor, alpha, against the reciprocal of the temperature. A temperature dependent reversal of the elution order between a pair of imidazole derivatives was studied. The results revealed that the main parameter determining interactions between imidazole derivatives and HP-beta-CD increased as follows: HP-beta-CD double left right arrow solute hydrogen bonding interaction > HP-beta-CD double left right arrow solute complexation.
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