Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 288-32-4, name is 1H-Imidazole, A new synthetic method of this compound is introduced below., 288-32-4
(a) 2,4,5-Tribromo-lH-imidazole[00355] To a solution of imidazole (60 g, 0.88 mol) in chloroform (360 mL) was added bromine (138 g, 1 mol) in chloroform (100 mL) dropwise at room temperature. Then the mixture was stirred for 1 h. After removing the solvent, the residue was suspended in hot water, filtered and dried in vacuo to provide 64 g of the desired product as a white solid. GC-MS: 304 (M+).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; SUNOVION PHARMACEUTICALS INC.; CAMPBELL, John, Emerson; HEWITT, Michael, Charles; JONES, Philip; XIE, Linghong; WO2011/150156; (2011); A2;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem