Related Products of 820959-17-9, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, 820959-17-9, Name is Ac-Beta-Ala-His-Ser-His-OH, SMILES is CC(NCCC(N[C@@H](CC1=CNC=N1)C(N[C@@H](CO)C(N[C@@H](CC2=CNC=N2)C(O)=O)=O)=O)=O)=O, belongs to imidazoles-derivatives compound. In a article, author is Yue, Yuanyuan, introduce new discover of the category.
Synthesis of imidazole derivatives and the spectral characterization of the binding properties towards human serum albumin
Small molecular drugs that can combine with target proteins specifically, and then block relative signal pathway, finally obtain the purpose of treatment. For this reason, the synthesis of novel imidazole derivatives was described and this study explored the details of imidazole derivatives binding to human serum albumin (HSA). The data of steady-state and time-resolved fluorescence showed that the conjugation of imidazole derivatives with HSA yielded quenching by a static mechanism. Meanwhile, the number of binding sites, the binding constants, and the thermodynamic parameters were also measured; the raw data indicated that imidazole derivatives could spontaneously bind with HSA through hydrophobic interactions and hydrogen bonds which agreed well with the results from the molecular modeling study. Competitive binding experiments confirmed the location of binding. Furthermore, alteration of the secondary structure of HSA in the presence of the imidazole derivatives was tested. (C) 2015 Elsevier B.V. All rights reserved.
Related Products of 820959-17-9, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 820959-17-9.