822-55-9, Name is 4-(Hydroxymethyl)imidazole, molecular formula is C4H6N2O, Recommanded Product: 4-(Hydroxymethyl)imidazole, belongs to imidazoles-derivatives compound, is a common compound. In a patnet, author is Macchiarulo, A, once mentioned the new application about 822-55-9.
1,4-benzothiazine and 1,4-benzoxazine imidazole derivatives with antifungal activity: A docking study
We have recently described the synthesis and antifungal activity of a series of 1,4-benzothiazine and 1,4-benzoxazine imidazole derivatives that mainly showed in vivo activity against a murine experimental model of candidiasis but that very often lacked in vitro activity. Here, we report a docking study of a representative set of our molecules in a 3D model of CYP51 of Candida albicans (CA-CYP51). The model was constructed on the basis of the sequence homology relationship with the recently reported crystal structure of the CYP51 of Mycobacterium tuberculosis (MT-CYP51). (C) 2002 Elsevier Science Ltd. All rights reserved.
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