Electric Literature of 1231930-33-8, These common heterocyclic compound, 1231930-33-8, name is 6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
DMSO (100 mL) was added to a 500 mL one-necked flask and the compound of formula XVI-1 (20.0 g,73.80 mmoL), bis (pinacolato) diboron (27.6 g, 108.69 mmol), tricyclohexylphosphine (3.53 g, 12.61 mmol)Potassium acetate (21.3 g, 217.38 mmol). Nitrogen gas was added to the reaction flask after the rapid addition of palladium acetate (1.5g), nitrogen PaulProtect the next open heating to 90C. After 3 hours the reaction flask was cooled to room temperature and the reaction mixture was poured into 700 mL of water, mixed thoroughly and subtractedPressure filtration, the filter cake was washed twice with 100mL of water and dried to give a light brown solid. Crude was added 50mL petroleum ether, 10mL BEthyl acetate beating 10min, vacuum filtration to give a white solid (18.8g, yield 80.3%)
The synthetic route of 1231930-33-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Zhengda Tianqing Pharmaceutical Group Co., Ltd.; Zhang Yinsheng; Liu Yingshuai; Qin Hui; Li Yuan; Zhao Kaidi; Miao Lei; Hu Jie; Liu Haiyan; Wang Xiaojin; (33 pag.)CN107266421; (2017); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem