These common heterocyclic compound, 51605-32-4, name is Ethyl 5-methyl-1H-imidazole-4-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Formula: C7H10N2O2
(1) Ethyl 4-methyl-1H-imidazole-5-carboxylate (7.5 g, 48.7mmol) was dissolved in acetonitrile (120 mE), N-bromosuccinimide (10.4 g, 58.4 mmol) was added thereto, and then themixture was stirred at room temperature for 3 hours. Afier thereaction, saturated aqueous sodium hydrogen carbonate wasadded and the mixture was extracted twice with ethyl acetate.Afier washing with saturated aqueous sodium chloride, theorganic layer was dried over anhydrous sodium sulfate. Afterconcentrating the organic layer, the residue was purified bycolunm chromatography to obtain ethyl 2-bromo-4-methyl-1 H-imidazole-5-carboxylate (3.6 g):(3H, s), 1.37 (3H, t, J=7.i Hz);j0127] iH.NMR (CDC13) oe: 4.35 (2H, q, J=7.i Hz), 2.51j0128] ESI-MS mlz=233 (M+H).
The synthetic route of Ethyl 5-methyl-1H-imidazole-4-carboxylate has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Teijin Pharma Limited; Maruyama, Akinobu; Kamada, Hirofumi; Fujinuma, Mika; Takeuchi, Susumu; Saitoh, Hiroshi; Takahashi, Yoshimasa; US2015/284358; (2015); A1;,
Imidazole – Wikipedia,
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