In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1615-14-1, name is 2-(1H-Imidazol-1-yl)ethanol belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. SDS of cas: 1615-14-1
To a solution of tert-butyl (5-(5-fluoro-1H-indazol-3-yl)-1,2,4-oxadiazol-3- yl)methy .carbamate (1.5 g, 4.50 mmol, 1 equiv.) in anhydrous toluene was added in order: l-(2-hydroxyethyl) imidazole (0.55 g, 4.95 mmol, 1.1 equiv.), 77-butyl phosphine (1.78 ml, 7.2 mmol, 1.6 equiv.) and TMAD (1.24 g, 7.2 mmol, 1.6 equiv.). The clear orange solution was allowed to stir under nitrogen overnight at room temperature. The toluene was then evaporated off in vacuo and the crude orange oil dissolved in ethyl acetate and washed with water, 1 HCl, IN NaOH and brine. The organic phase was dried over magnesium sulfate and the solvent vacced off.
The synthetic route of 1615-14-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; UNIVERSITY COLLEGE LONDON; POSADA, Cristina, Garcia; SELWOOD, David; GARTHWAITE, John; BAKER, David; CLUTTERBUCK, Lisa; WO2011/61469; (2011); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem