Extended knowledge of 6154-30-9

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 6154-30-9, name is 2,5-Dibromo-4-nitro-1H-imidazole, A new synthetic method of this compound is introduced below., Quality Control of 2,5-Dibromo-4-nitro-1H-imidazole

Reference Example 1Synthesis of l-ethoxymethyl-2, 5-dibromo-4- nitroimidazoleA mixture of 2, 5-dibromo-4-nitroimidazole (20.0 g, 73.8 mmol) , ethylal (100 ml), and methanesulfonic acid (1.42 g, 14.8 mmol) was stirred under heating (bath temperature: 65 to 70C, internal temperature: 60C, 1.5 hours) . Further, the reaction mixture was evaporated under reduced pressure for two hours (fractional distillation column was used) . The residue was allowed to cool to room temperature, and EPO then ice water (200 g) was added, and the mixture was stirred for 10 minutes. The filtered crystals were washed with cold water and then air-dried (room temperature, 3 days) . Thus, l-ethoxymethyl-2, 5- dibromo-4-nitroimidazole was produced. Yield: 23.5g (96.8%) IR spectrum (KBr) :1532, 1491, 1464, 1397, 1365, 1344, 1315, 1273, 1248, 1127, 1106, 1054, 1020, 830, 740cm”1 1H-NMR spectrum (CDCl3) deltappm:1.25 (t, J=7.0Hz, 3H), 3.64 (q, J=7.0Hz, 2H), 5.50 (s, 2H) .

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; OTSUKA PHARMACEUTICAL CO., LTD.; WO2006/35960; (2006); A2;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem