Reference of 20485-43-2,Some common heterocyclic compound, 20485-43-2, name is 1-Methyl-1H-imidazole-2-carboxylic acid, molecular formula is C5H6N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Methyl 4- [ (TERT-BUTOXYCARBONYL) AMINO]-L-METHYLPYRROLE-2-CARBOXYLATE (0. 1108 g, 0.43 mmol) in 4 M HC1/ETOAC (4.26 ml) was stirred at room temperature for 30 min. The solvent was removed under reduced pressure and dried under vacuum for 1 hr. The residue was dissolved in DMF (4 ml) and ImCOOH (0.059 g, 0.52 mmol, 1. 2 equiv) was added followed by HOBt (0.079 g, 0.65 mmol, 1.5 equiv), TBTU (0.189 g, 0.65 mmol) and Et3N (0.328 ml, 2.6 mmol, 6 equiv) and the solution stirred for 1 hr. Solvent was removed and purified by flash chromatography (0-5 % MEOH/DCM).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Methyl-1H-imidazole-2-carboxylic acid, its application will become more common.
Reference:
Patent; UNIVERSITY OF WESTERN SYDNEY; WO2005/33077; (2005); A1;,
Imidazole – Wikipedia,
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