Application of 15469-97-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 15469-97-3, name is 1-Trityl-1H-imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
Example 1 Synthesis of 2-chloroimidazole (2-cim) To a 300-mL, three-neck, round-bottom flask equipped with a magnetic stirrer and argon inlet, were added N-tritylimidazole (3.14 g, 0.01 mol) and anhydrous THF (140 mL). The stirrer was started, and the solution was cooled to -78 C. (acetone/dry ice). n-BuLi (2.5 M in hexanes, 8.0 mL, 0.02 mol) was added via syringe resulting in reddish solution. This solution was stirred for 60 min whereupon hexachloroethane (5.0 g, 0.021 mol) in THF (25 mL) was added in portions. The reaction mixture was stirred for 1 additional hour and then quenched with saturated aqueous ammonium chloride (100 mL). The cooling bath was removed, and when the reaction flask reached room temperature the contents were transferred to a 500 mL separatory funnel, and extracted with ethyl acetate (50 mL*2). The organic layer was separated, washed with water and brine, and dried over anhydrous sodium sulfate. After filtration, the solvents were evaporated under reduced pressure resulting in a slightly yellow solid. The solid was refluxed with 5% acetic acid in methanol (75 mL) for 24 hours. Upon evaporation of the solvent, water was added to the residue. Extraction with hexanes effectively removed the triphenylmethane impurity. Evaporation of water in vacuo afforded off-white solid as pure 2-chloroimidazole (2-cim, 0.70 g, 69% overall yield from N-triylimidazole).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Trityl-1H-imidazole, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY; US2011/282067; (2011); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem