Synthetic Route of 2466-76-4, The chemical industry reduces the impact on the environment during synthesis 2466-76-4, name is 1-(1H-Imidazol-1-yl)ethanone, I believe this compound will play a more active role in future production and life.
Triethylamine (217 mg, 2.15 mmol), followed by 1-acetylimidazole (95 mg, 0.86 mmol), was added to a solution of the product from step 2 (200 mg, 0.43 mmol) in methylene chloride (5 mL). The reaction mixture was stirred at room temperature for 16 h. The solvent was removed under reduced pressure. The residue was dissolved in methanol (6 mL) and water (3 mL) and treated with potassium carbonate (300 mg, 2.17 mmol). The reaction mixture was stirred at room temperature for 2 h. The solvent was removed under reduced pressure. The residue was acidified with 1 N hydrochloric acid and extracted with ethyl acetate. The combined extracts were washed with saturated sodium chloride, and dried (sodium sulfate), filtered, and concentrated under reduced pressure. Purification by flash column chromatography (silica gel, 0-5percent methanol/methylene chloride provided the desired product (85 mg, 49percent) as a white foam. ESI MS m/z 407 [C2, H24F2N204 + H] + ; HPLC (Phenomenex Luna C18 (2) Column, 150 x 4.6 mm, 5R ; A: 0.05percent TFA in 95: 5 H20/CH3CN ; B: 0.05percent TFA in 5: 95 H20/CH3CN ; Gradient: 30-100percent B over 15 min; flow 1.0 mUmin ; Detection: 254 nm) 98.0percent (AUC), tR = 7.01 min. Anal. Calc’d for C21H24F2N2O4No.O. 25 H20 : C, 61.38 ; H, 6.01 ; N, 6.82 ; found: C, 61.60 ; H, 5.68 ; N, 6.59.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-(1H-Imidazol-1-yl)ethanone, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; ELAN PHARMACEUTICALS, INC.; WO2005/87714; (2005); A2;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem