In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 14741-71-0, name is Ethyl 2-(1H-benzo[d]imidazol-2-yl)acetate belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: Ethyl 2-(1H-benzo[d]imidazol-2-yl)acetate
Ethyl 2-BENZIMIDAZOL-2-YLACETATE (1.1 equivalents) and 2-amino- 5-(4-METHYLPIPERAZINYL) BENZENECARBONITRILE (1.0 equivalent) were dissolved in 1, 2-dichloroethane, and then SNCL4 (11 equivalents) was added. The mixture was heated at reflux overnight. Upon cooling, the mixture was concentrated in vacuo. NAOH (3 M) was added to the solid, and the mixture heated at 80 C for 0.5 hours. The solid was filtered and washed sequentially with H2O, CH2CI2, and acetone. LC/MS indicated that the product was present in the acetone layer and the solid. These fractions were combined and purified by silica gel chromatography (5-10% MeOH in CH2CI2 with 1 % ET) to give the desired product. LC/MS M/Z 375.4 (MH+), Rt 1.65 minutes.
The synthetic route of 14741-71-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; CHIRON CORPORATION; WO2004/18419; (2004); A2;,
Imidazole – Wikipedia,
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