Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 96797-15-8, name is 4-Iodo-1-trityl-1H-imidazole, A new synthetic method of this compound is introduced below., SDS of cas: 96797-15-8
4-Iodo-1-trityl-1H-imidazole (5, 2 g, 4.58 mmol), (5-chloro-2-methoxyphenyl)boronic acid(0.852 g, 4.58 mmol), K3PO4 (2.9 g, 13.7 mmol), Pd(PPh3)4 (0.74 g, 0.64 mmol) were added todry dimethylformamide (30 mL). The reaction mixture was stirred at 100 C under inert atmosphere,until the starting material disappeared in TLC. The reaction mixture was distilled in vacuo, and ethylacetate (100 mL) was added to the mixture. The organic extract was washed twice with saturatedaqueous NaCl (20 mL), and the organic extract was dried over Na2SO4. After solvent was removedunder vacuum, the product was purified as a white solid by silica gel column chromatography, 1.2 g,yield 63%. 1H-NMR (400 MHz, CDCl3): = 7.51-7.32 (m, 12H, H-phenyl, H-imidazolyl), 7.15-7.04 (m,8H, H-phenyl, H-imidazolyl), 6.94 (d, J = 8.1 Hz, 1H, H-phenyl), 3.99 (s, 3H, CH3). HRMS (ESI): m/z[M + H]+ calculated for C29H25N2O: 417.19614; found: 417.19647.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Wen, Hui; Liu, Yuke; Wang, Shufang; Wang, Ting; Zhang, Gang; Chen, Xiaoguang; Li, Yan; Cui, Huaqing; Lai, Fangfang; Sheng, Li; Molecules; vol. 24; 11; (2019);,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem