In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 51605-32-4, name is Ethyl 5-methyl-1H-imidazole-4-carboxylate belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Application In Synthesis of Ethyl 5-methyl-1H-imidazole-4-carboxylate
Add DIAD (2.01 g, 9.74 mmol) dropwise at 0-5 ¡ãC under nitrogen followed by 2,2-difluoroethanol (0.64 g, 7.79 mmol) to a stirring solution of ethyl 4-methyl-1H-imidazole-5-carboxylate (1.00 g, 6.49 mmol) and triphenylphosphine (2.60 g, 9.71 mmol)THF (20 mL). Stir the mixture at 10-15 ¡ãC for 16 hrs. Concentrate the mixture and purify by silica gel combi-flash chromatography eluting with EtOAc in PE from 10percent to 35percent to give the title compound (0. 47 g, 33.2percent) as yellow oil. LC/MS (mlz): 219 (M+H).
The synthetic route of 51605-32-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ELI LILLY AND COMPANY; LILLY CHINA RESEARCH AND DEVELOPMENT CO., LTD.; HU, Zhilong; LIU, Lianzhu; MA, Tianwei; ZENG, Mi; ZHANG, Haizhen; (37 pag.)WO2018/14800; (2018); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem