Application of 33468-69-8, The chemical industry reduces the impact on the environment during synthesis 33468-69-8, name is 4-(Trifluoromethyl)-1H-imidazole, I believe this compound will play a more active role in future production and life.
Example 35 Synthesis of 1- [l-(4-fluorophenyl)-5-isopropylpyrazol-4-yl] -3- [4- [0190] A mixture of 3-bromo-l-[l-(4-fluorophenyl)-5-isopropyl-pyrazol-4-yl]pyrrolidin-2- one (0.020 g, 0.055 mmol), 4-(trifluoromethyl)- lH-imidazole (0.024 g, 0.17 mmol) and K2C03 (0.030 g, 0.22 mmol) in DMF (0.6 mL) was stirred at 60 C for 1 hr. The mixture was then cooled to room temperature, quenched with water (30 mL) and extracted with EtOAc (50 mL). The organic layer was separated, dried over anhydrous sodium sulfate, concentrated in vacuo and purified by reverse phase HPLC (CI 8 column, acetonitrile-H20 with 0.1% TFA as eluent) to yield the title compound (0.022 g, TFA salt, 75%); XH NMR (TFA salt) (400 MHz, CDC13) delta 7.98 (s, 1 H), 7.59 (s, 1 H), 7.51 (s, 1 H), 7.39 (dd, J= 8.4, 4.8 Hz, 2 H), 7.20 (dd, J= 8.6, 8.6 Hz, 2 H), 5.06 (dd, J= 10.8, 8.8 Hz, 1 H), 3.90 (m, 1 H), 3.83 (m, 1 H), 2.98 (m, 2 H), 2.54 (m, 1 H), 1.21 (d, J= 7.2 Hz, 3 H), 1.20 (d, J= 7.2 Hz, 3 H); MS: (ES) m/z calculated for (free form) [M + H]+ 422.1, found 422.1.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-(Trifluoromethyl)-1H-imidazole, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; CHEMOCENTRYX, INC.; CHEN, Xi; FAN, Pingchen; LI, Yandong; POWERS, Jay P.; MALATHONG, Viengkham; PUNNA, Sreenivas; TANAKA, Hiroko; ZHANG, Penglie; WO2014/89495; (2014); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem