Related Products of 32673-41-9, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 32673-41-9 as follows.
A mixture of 600 mg (4.36 mmol) of 4-hydroxymethylimidazol hydrochloride, 1.84 g (13.4 mmol) of anhydrous potassium carbonate, 40 mL of dimethylsulfoxide, and 1 g (3.61 mmol) of 3-(3,4-difluorophenyl)-5-(3-isoxazoylaminomethyl)isoxazole (Intermediate 7) was heated at 90C with stirring for 24 h under an inert atmosphere, allowed to cool, poured over 400 mL of a saturated sodium chloride solution, and extracted three times with 300 mL of ethyl acetate. The extracts were dried over anhydrous sodium sulfate, and filtered. The solvent was distilled off under reduced pressure and the obtained residue was chromatographed on a silica gel column with dichloromethane/methanol (20:1) as eluant. 300 mg (yield = 23 %) of a yellow solid were obtained. IR (KBr): 3300, 3100, 1595 cm-1. Mass spectrum (m/e): 355 (M+). 1H-NMR (200 MHz, CDCl3, ? ppm): 8.44 (s, 1H), 8.20-6.95 (m, 8H), 6.1 (s, 1H), 4.50 (d, 2H), 3.30 (s, 2H), 3.00 (br, 2H).
According to the analysis of related databases, 32673-41-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; LABORATORIOS S.A.L.V.A.T., S.A.; EP1437349; (2004); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem