Related Products of 96797-15-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 96797-15-8, name is 4-Iodo-1-trityl-1H-imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
Step 40.a. (R,S) 4-(Hydroxy-(1-trityl-1H-imidazol-4-yl)-methyl)-benzonitrile A solution of 1-trityl-4-iodoimidazole (3.53g, 8.10mmol) in CH2Cl2 (35ml) was cooled to about -3C under N2 and 3M EtMgBr in Et2O was added dropwise while maintaining reaction temperature at below about 0C. The solution was stirred for about one hour at about 0C and then 4-cyanobenzaldehyde (1.18g, 9.00mmol) was added in one portion and the reaction was allowed to warm to room temperature for about 1 hour.. The reaction mixture was then again cooled to about 0C and 5% HCl (30ml) was added.. The reaction mixture was stirred about 15 min. and then extracted with CH2Cl2 (2x25ml).. The combined CH2Cl2 layers were washed with saturated NaHCO3, dried over Na2SO4, filtered, and then concentrated under reduced pressure.. The residue was triturated with EtOAc (25ml) and the product filtered off (2.92g, 82%).. Mass spec. 442.3 MH+, NMR (300MHZ, DMSO-d6, 30C) 7.7-7.8 (2H, d), 7.5-7.6 (2H, d), 7.3-7.5 (9H, m), 7.25-7.3 (1H, s), 7.0-7.15 (6H, m), 6.75-6.8 (1H, s), 5.9-6.90 (1H, m), 5.6-5.7 (1H, m).
The synthetic route of 4-Iodo-1-trityl-1H-imidazole has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SOCIETE DE CONSEILS DE RECHERCHES ET D’APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.); EP1382607; (2004); A2;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem