Electric Literature of 14741-71-0, A common heterocyclic compound, 14741-71-0, name is Ethyl 2-(1H-benzo[d]imidazol-2-yl)acetate, molecular formula is C11H12N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: LHMDS (1.65 mL, 1 M in THF, 1.65 mmol, 5.0 equiv) was added dropwise to a solution of ethyl 2-(1H-benzo[d]imidazol-2-yl)acetate (67.6 mg, 0.33 mmol, 1.0 equiv) and 1-(4-methoxybenzy-l)-1H-thieno[2,3-d][1,3]oxazine-2,4-dione (0.33 mmol, 1.0 equiv) in anhydrous THF (15 mL) at -78 C. The resulting solution was slowly warmed to room temperature and then stirred overnight at 80 C. After the reaction completed, quenched with a small amount of NH4Cl (aq, satd). And then concentrated in vacuo, the resulting crude material was purified by column chromatography (petroleum ether/ethyl acetate/acetic acid = 500:100:20, v/v/v) on silica gel to afford the product as a white solid.
The synthetic route of 14741-71-0 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Song, Pinrao; Peng, Peng; Han, Mengmeng; Cao, Xianchao; Ma, Xiaodong; Liu, Tao; Zhou, Yubo; Hu, Yongzhou; Bioorganic and Medicinal Chemistry; vol. 22; 17; (2014); p. 4882 – 4892;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem