Related Products of 312-73-2, A common heterocyclic compound, 312-73-2, name is 2-(Trifluoromethyl)-1H-benzo[d]imidazole, molecular formula is C8H5F3N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Compound II (60.00g, 0.322mol, 1.0eq.) And cesium carbonate (159.98g, 0.483mol, 1.5eq.) Were added to 600mL DMF, and ethyl iodide (75.33g, 0.483mol, 1.5) was added dropwise at 0 C. eq.), the reaction was completed at 25 C for 1h after the addition, TLC showed that the raw materials had reacted, the system was poured into 1L of ice water, washed with water (100mL * 2), filtered to obtain a white solid, washed with water (100mL * 2), white The solid was dissolved with ethyl acetate, dried over anhydrous magnesium sulfate, and concentrated to obtain compound III-2 as a white solid 61.01g, yield: 88.5%.
The synthetic route of 312-73-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Nanjing Yaoshi Technology Co., Ltd.; Wang Zhengjiang; Xia Aihua; (15 pag.)CN110903245; (2020); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem