Reference of 2302-25-2,Some common heterocyclic compound, 2302-25-2, name is 4-Bromo-1H-imidazole, molecular formula is C3H3BrN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A mixture of 4-bromopyridin-2-ol (0.49 g, 2.82 mmol), l-tetrahydropyran-2-yl-4-(4,4,5,5- tetramethyl-l,3,2-dioxaborolan-2-yl)pyrazole (0.86 g, 3.10 mmol), granular K2CO3 (1.17 g, 8.47 mmol), PdCl2(dppf) (0.10 g, 0.14 mmol), l,4-dioxane (12 mL), and H20 (5 mL) was stirred at 80 C under an argon atmosphere overnight. The reaction mixture was diluted with brine (40 mL), and extracted with dichloromethane (2 x 60 mL). The extracts were combined, dried over anhydrous MgS04, filtered, and the filtrate was concentrated to dryness on a rotovap. The crude material was purified on a silica gel column (methanol in dichloromethane, 0-50%) to afford the desired 4-(l-tetrahydropyran-2-ylpyrazol-4-yl)pyridin-2-ol (0.56 g, 81%) as a white, fluffy powder. LC-MS 246.3 [M+H]+, RT 1.05 min.
The synthetic route of 2302-25-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PTC THERAPEUTICS, INC.; CHEN, Guangming; BHATTACHARYYA, Anuradha; JIANG, Yao; KARP, Gary, Mitchell; NARASIMHAN, Jana; TURPOFF, Anthony; ZHANG, Nanjing; (0 pag.)WO2020/5882; (2020); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem