Reference of 33468-69-8, The chemical industry reduces the impact on the environment during synthesis 33468-69-8, name is 4-(Trifluoromethyl)-1H-imidazole, I believe this compound will play a more active role in future production and life.
0.6 g of intermediate 2-3, 4- (trifluoromethyl) imidazole 0.36 g and toluene 0.74 g of potassium carbonate,0.26 mL of trans-N, N’-dimethylcyclohexane-1,2-diamine and 0.15 g of copper iodide were added.The reaction mixture was stirred at 120 C. for 24 hours,After cooling to room temperature, water was added and the mixture was extracted with ethyl acetate.The obtained organic layer was washed with saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure.The obtained residue was subjected to silica gel chromatography (hexane: ethyl acetate = 3: 2) to obtain 0.32 g of the active compound A-12 shown below.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-(Trifluoromethyl)-1H-imidazole, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; SUMITOMO CHEMICAL COMPANY LIMITED; MURAKAMI, SHINICHIRO; (291 pag.)JP2018/76354; (2018); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem