Some common heterocyclic compound, 1402838-08-7, name is 2-(1-Trityl-4-imidazolyl)benzaldehyde, molecular formula is C29H22N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. category: imidazoles-derivatives
A slurry of tert-butyl 2?-oxospiro[8-azabicyclo[3 .2.1 ]octane-3, I ?-cyclobutanej-8-carhoxylate (2.65 g, 9.98 .mmol), 2-[ 1.-(triphenylmethyl)- IH-imidazol-4-yl.]benzaldehyde (4.55 g,11.0 mmol) and Ca(OH)2 (1.48 g, 20.0 mmol) in EtOH (33 mL) was stirred for 24 h at 80 C.The reaction was cooled to room temperature and insoluble material was removed by filtration. The filtrate was concentrated. The residue was purified by a silica gel column eluting withDCM/methanoj. (90:10) to afford 5.60 g (85%) tertbutyl E)-2?-oxo-3?(2-(1-trity1-1Wirnidazo1.-4-yl)benzylidene)-8-azaspiro[bicyclo{3 .2.1 ]octane-3, 1 ?-cyclobutane]-S-carboxylate as a pale yellow solid. LCM.S (ESI) m/z 662.3 [M+F1]4.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1402838-08-7, its application will become more common.
Reference:
Patent; GENENTECH, INC.; PEI, Zhonghua; PASTOR, Richard; GAZZARD, Lewis; PARR, Brendan; LIU, Wendy; MENDONCA, Rohan; WU, Guosheng; YUEN, Po-Wai; (183 pag.)WO2019/5559; (2019); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem