Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 492-98-8, name is 1H,1’H-2,2′-Biimidazole, A new synthetic method of this compound is introduced below., Formula: C6H6N4
Synthetic example 10:1 , 1 ‘-bis(6-methyl-9-p-tolyl-9H-carbazol-3-y.)-1 H, 1 ,H-2,2i-biimidazole10A mixture of 1W, W-2,2*-biimidazole (890 mg, 6.6 mmol), 3-bromo-6-methyl-9-p-tolyl- 9H-carbazole (6.49 g, 18.6 mmol) and Cs2C03 (7.55 g, 23.2 mmol) in D F (80 mL) was degassed (N2 bubbling, 15 min). Cu20 (380 mg, 2.7 mmol) was added and the mixture was heated (140 C, 96h). The mixture was allowed to cool to room temperature and filtered through Celite washing with CH2CI2. The combined filtrate and washings were concentrated. The mixture was diluted with CH2CI2 and H2O and the organic phase was separated. The aqueous phase was re-extracted (CH2CI2) and the combined organics were washed (saturated aqueous NaCI), dried (MgS04), filtered and concentrated to give a solid residue. The residue was purified by flash chromatography (EtOAc CH2CI2/ eOH 39:60:1 then 37:60:3 then 35:60:5) to give l.r-bisie-methyl-g-p-tolyl-gH-carbazol-S-y -IH.rH^^’-biimidazole (1.42 g, 32%) as a colourless solid. A portion of this material was further purified firstly, by recrystallisation (CH2CI2/toluene/petrol) and then by distillation (sublimation apparatus 270 C, 1CT6 mBar): m.p. 208 – 214 C (DSC); 1H N R (CDCI3, 400 MHz) delta 2.38 (s, 6H), 2.49 (s, 6H), 6.71 (dd, J 1.8, 8.7 Hz, 2H), 7.03 (d, J 8.6 Hz, 2H), 7.05 – 7.20 (m, 8H), 7.23 – 7.40 (m, 12H); 13C NMR (CDCI3, 100 MHz) 5 21.2, 21.3, 109.4, 109.4, 115.7, 119.7, 121.8, 122.4, 123.1, 126.5, 127.8, 129.3, 129.6, 130.4, 134.6, 137.4, 139.6, 139.7; HRMS (El) m/z 671.2916 C46H35 6 [M – Hf* requires 671.2918
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION; MACDONALD, James Matthew; BOWN, Mark; UENO, Kazunori; WEBER, Karl Peter; O’CONNELL, Jenny Lee; HIRAI, Tadahiko; WO2012/51666; (2012); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem