Synthetic Route of 124312-73-8, These common heterocyclic compound, 124312-73-8, name is (1-Methyl-1H-imidazol-2-yl)methanamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: To a solution of 7-chloro-2,5-dimethyl-3-phenylpyrazolo[1,5-a]pyrimidine (1 equiv) and diisopropylethylamine (1.5 equiv) in 2-propanol was added amine (1.2 equiv). After refluxing for 16 h, the reaction mixture was concentrated in vacuo and the appropriate solvent added to precipitate the crude product, which was collected by filtration and then purified by recrystallization, prep HPLC or column chromatography.
The synthetic route of 124312-73-8 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Candice, Soares De Melo; Feng, Tzu-Shean; Van Der Westhuyzen, Renier; Gessner, Richard K.; Street, Leslie J.; Morgans, Garreth L.; Warner, Digby F.; Moosa, Atica; Naran, Krupa; Lawrence, Nina; Boshoff, Helena I.M.; Barry, Clifton E.; Harris, C. John; Gordon, Richard; Chibale, Kelly; Bioorganic and Medicinal Chemistry; vol. 23; 22; (2015); p. 7240 – 7250;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem