Electric Literature of 53710-78-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 53710-78-4, name is 1-(3-Chloropropyl)-1H-imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
Under ice-cooling, 1-(3-chloropropyl)-1H-imidazole (1.90 g, 13.14 mmol), cesium carbonate (4.28 g, 13.14 mmol) and a catalytic amount of potassium iodide were dissolved in DMF (30 mL).2-Fluoro-4-nitroaniline (1.38 g, 8.84 mmol) was added in one portion and the reaction was heated to reflux for 36 h.After the reaction was completed, the mixture was cooled to room temperature, filtered, and the solvent was evaporated under reduced pressure. The residue was added to water (50 mL) and extracted with dichloromethane (20 mL ¡Á 2).The organic phase was washed with saturated brine (20 mL¡Á2), the solvent was evaporated under reduced pressure, and the crude product was purified by column chromatography (dichloromethane/methanol (V/V)=15/1).A yellow oil (2.85 g, 82%) was obtained.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-(3-Chloropropyl)-1H-imidazole, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, YINGJUN; ZHANG, JIANCUN; WANG, XIAOJUN; LIN, RUNFENG; CAO, SHENGTIAN; WANG, ZHAOHE; LI, JING; (226 pag.)TWI607995; (2017); B;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem