29043-48-9, name is 2-Methyl-1H-benzoimidazol-5-ylamine, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 29043-48-9
A solution of 75 mg (0.10 mmol) of (2S) -2- {[(iraws-4- {[(ieri-butoxycarbonyl) – amino] methyl}cyclohexyl) carbonyl] amino} -3- (4 ‘- {[1 – (ieri-butoxycarbonyl) -piperidin-4-yl] – carbamoyl} -2’-methyl-biphenyl-4-yl) propanoic acid and 31 mg (0:21 mmol) of 2-methyl-l / ibenzimidazol-5-aminewas dissolved in 1 ml of dichloromethane containing 0.05 ml (0:31 mmol) of N, N-diisopropylamineand 81 mg (0:16 mmol) of (l / i-benzotriazol-l-yloxy) (tripyrrolidin-lyl) phosphoniumhexafluorophosphate was added and stirred for 16 h at RT. The reaction solution was separatedby preparative HPLC (eluent: acetonitrile / water gradient, 0.01% to trifluoroacetic acid). Theproduct-containing fractions were combined and concentrated on a rotary evaporator. There were23 mg (26% d. Th.) Of the title compound.
The synthetic route of 29043-48-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; ROEHN, ULRIKE; ELLERMANN, MANUEL; STRASSBURGER, JULIA; WENDT, ASTRID; ROEHRIG, SUSANNE; WEBSTER, ROBERT ALAN; SCHMIDT, MARTINA VICTORIA; TERSTEEGEN, ADRIAN; BEYER, KRISTIN; SCHAEFER, MARTINA; BUCHMUELLER, ANJA; GERDES, CHRISTOPH; SPERZEL, MICHAEL; SANDMANN, STEFFEN; HEITMEIER, STEFAN; HILLISCH, ALEXANDER; ACKERSTAFF, JENS; TERJUNG, CARSTEN; (489 pag.)TW2016/5810; (2016); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem