Adding a certain compound to certain chemical reactions, such as: 2302-25-2, name is 4-Bromo-1H-imidazole, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2302-25-2, SDS of cas: 2302-25-2
Step A. (Z -4-(3-(4-(4-Bromo- lH-imidazol- 1 -yl but-2-en- 1 -yr)-4,4-dimethyl-2,5- dioxoimidazolidin- 1 -yl)-2-(trifluoromethyl)benzonitrile. A mixture of (Z)-4-(3-(4-chlorobut-2-en-l-yl)-4,4-dimethyl-2,5-dioxoimidazolidin-l-yl)-2- (trifluoromethyl)benzonitrile (500 mg, 1.3 mmol), 4-bromo-lH-imidazole (191 mg, 1.3 mmol), and K2C03 (359 mg, 2.6 mmol) in DMF (5 mL) was stirred at room temperature for 5 hours. The reaction mixture was poured into water (20 mL) and extracted with ethyl acetate (20 mL x 3). The extracts were combined, washed with brine (30 mL), dried over sodium sulfate, filtered, and concentrated under reduced pressure to afford (Z)-4-(3-(4-(4- bromo- 1 H-imidazol- 1 -yl)but-2-en- 1 -yl)-4,4-dimethyl-2,5-dioxoimidazolidin- 1 -yl)-2- (trifiuoromethyl)benzonitrile as a white solid (600 mg, 93%). LCMS (ESI) m/z: 496.1 [M+H]+.
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Reference:
Patent; BEAUFOUR-IPSEN (TIANJIN) PHARMACEUTICAL CO., LTD.; AUVIN, Serge; LANCO, Christophe; DUTRUEL, Oliver; CHAO, Qi; GU, Kaichun; WO2015/100617; (2015); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem