Nitroimidazoles, part XXIII – activity of satranidazole series against anaerobic infections was written by Nagarajan, K.;Gowrishankar, R.;Arya, V. P.;George, T.;Nair, M. D.;Shenoy, S. J.;Sudarsanam, V.. And the article was included in Indian Journal of Experimental Biology in 1992.Recommanded Product: 3034-41-1 This article mentions the following:
A large number of nitroimidazoles were examined for in vitro activity against 3 anaerobes – Bacteroides fragilis (Bf), a strain of Bf resistant to metronidazole (I) and Clostridium perfringens and many found to be active. Among these may be mentioned 1-methyl-5-nitroimidazoles carrying N-bound heterocycles at position 2, such as satranidazole (II) and III (R1 = H, R2 = SO2Et, SO2NMe2, morpholinylcarbonyl, morpholinoethylaminothioxomethyl) which are at least twice as active as I, ornidazole (IV) and tinidazole (V). Even more active are 5-nitroimidazolylbenzimidazole, -thiazolidinone, and -thiadiazolidine dioxide. Many other types of compounds derived from 1-methyl-2-amino-5-nitroimidazole are feebly active. Among 5-nitroimidazoles with a carbon substituent at position 2, I, IV and V are equiactive while dimetridazole is more active than I against Bf. Some 2-vinyl derivatives are very potent, with VI and VII being outstanding. Activity better than I is seen for nitroimidazooxazepines. 5-Nitroimidazoles are more active against anaerobes than the 4-nitro isomers. Antianaerobic and antiamoebic activities generally run parallel in these classes of compounds The study has led to the elaboration of the antianaerobic profile of II. In the experiment, the researchers used many compounds, for example, 1-Methyl-4-nitroimidazole (cas: 3034-41-1Recommanded Product: 3034-41-1).
1-Methyl-4-nitroimidazole (cas: 3034-41-1) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Recommanded Product: 3034-41-1
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem