Michael adducts in the regioselective synthesis of N-substituted azoles was written by Horvath, Andras. And the article was included in Synthesis in 1995.Quality Control of 7-Methyl-1H-benzo[d]imidazole This article mentions the following:
Michael adducts of azoles (4-phenyl-, 4-methyl-, and 4-nitroimidazole, 4-methylbenzimidazole, 1,2,4-triazole, and theophylline) are shown to be valuable substrates for obtaining the N-substituted derivatives of the parent heterocycles by a quaternization-Hofmann elimination sequence. The effectiveness of the procedure is dependent on the regiochem. outcome of the 1st, N-protective step, i.e. the Michael addition By choosing the appropriate Michael acceptor, alkylating agent, and deprotection conditions, the thermodynamically less stable regioisomers of N-substituted azoles were obtained in high yields. In the experiment, the researchers used many compounds, for example, 7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6Quality Control of 7-Methyl-1H-benzo[d]imidazole).
7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Quality Control of 7-Methyl-1H-benzo[d]imidazole
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem