Radiosensitizing, toxicological, and pharmacokinetic properties of hydroxamate analogs of nitroimidazoles as bifunctional radiosensitizers/chemical modifiers was written by Nagasawa, Hideko;Bando, Masahiro;Hori, Hitoshi;Satoh, Tetsuo;Tada, Takuhito;Onoyama, Yasuto;Inayama, Seiichi. And the article was included in International Journal of Radiation Oncology, Biology, Physics in 1992.Category: imidazoles-derivatives This article mentions the following:
The pharmacokinetics were examined of KIH-802, potassium 2-nitroimidazole-1-acetohydroxamate, using its radioisotope-labeled compound and the acute toxicity in mice. The concentration of KIH-802 was very low in the brain and its LD50 was nearly half the value of that of MISO. Here, new 2-nitroimidazole radiosensitizers/chem. modifiers (KIN-804, 811, 831, 841, 844, 821, 823 and 824) were designed to enhance their sensitizing ability intensely by substituting various biol. active groups, such as hydroxamic acids and oximes, with moderate lipophilicity to the aromatic ring, if necessary, through some spacers. The sensitizing effects of all compounds were estimated to be almost equal to or better than that of MISO. The results of their toxicities shows that new hydroxamates KIN-804 and 831 are less toxic than KIH-802 and MISO. Their in vitro enhancement ratios are 2.00 and 1.75, resp., compared with those of KIH-802, MISO and SR-2508, 1.77, 1.72 and 1.72, resp., at each dose of 1 mM for EMT6/KU single cell. It is concluded that they hydroxamic acid analogs to KIH-802 may be superior radiosensitizers. In the experiment, the researchers used many compounds, for example, 2-(2-Nitro-1H-imidazol-1-yl)acetic acid (cas: 22813-32-7Category: imidazoles-derivatives).
2-(2-Nitro-1H-imidazol-1-yl)acetic acid (cas: 22813-32-7) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Category: imidazoles-derivatives
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem