Microwave-Accelerated Cross-Dehydrogenative Coupling of Quinoxalin-2(1H)-ones with Alkanes under Transition-Metal-Free Conditions was written by Wang, Min;Zhang, Zhongyi;Xiong, Chunxia;Sun, Peipei;Zhou, Chao. And the article was included in ChemistrySelect in 2022.Synthetic Route of C8H8N2 This article mentions the following:
With simple alkanes as the alkyl radical precursors under microwave irradiation, a convenient and efficient cross-dehydrogenative alkylation reaction of quinoxalin-2(1H)-ones and other N-heteroarenes was achieved. The protocol demonstrates a broad substrate scope, good functional group tolerance, high atom economy and high efficiency, providing a wide range of valuable, structurally diverse C3 alkylated quinoxalin-2(1H)-ones and other alkylated N-heteroarenes in good-to-excellent yields. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Synthetic Route of C8H8N2).
1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Synthetic Route of C8H8N2
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem