A simplified synthesis of 2,3,5,6-tetrafluorophenyl 2-(2-nitroimidazol-1-yl) acetate was written by Wilson, Hanna. And the article was included in Journal of Labelled Compounds & Radiopharmaceuticals in 2003.Safety of 2-(2-Nitro-1H-imidazol-1-yl)acetic acid This article mentions the following:
2-Nitro-1H-Imidazole-1-acetic acid (2,3,5,6-tetrafluorophenyl) ester was synthesized via an improved route which involves the direct coupling of 2-(2-nitroimidazol-1-yl)acetic acid with 2,3,5,6-tetrafluorophenol. This ester is an intermediate for 18F-fluorinated derivatives of 2-nitro-N-(2,3,3-trifluoropropyl)-1H-imidazole-1-acetamide or fluoroetanidazole. In the experiment, the researchers used many compounds, for example, 2-(2-Nitro-1H-imidazol-1-yl)acetic acid (cas: 22813-32-7Safety of 2-(2-Nitro-1H-imidazol-1-yl)acetic acid).
2-(2-Nitro-1H-imidazol-1-yl)acetic acid (cas: 22813-32-7) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Safety of 2-(2-Nitro-1H-imidazol-1-yl)acetic acid
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem