Ligand-Promoted RhI-Catalyzed C2-Selective C-H Alkenylation and Polyenylation of Imidazoles with Alkenyl Carboxylic Acids was written by Zhao, Haoqiang;Luo, Zhenli;Yang, Ji;Li, Bohan;Han, Jiahong;Xu, Lijin;Lai, Wenzhen;Walsh, Patrick J.. And the article was included in Chemistry – A European Journal in 2022.Product Details of 83741-35-9 This article mentions the following:
The first RhI-catalyzed, directed decarbonylative C2-H alkenylation of imidazoles with readily available alkenyl carboxylic acids is reported. The reaction proceeds in a highly regio- and stereoselective manner, providing efficient access to C2-alkenylated imidazoles that are generally inaccessible by known C-H alkenylation methods. This transformation accommodates a wide range of alkenyl carboxylic acids, including challenging conjugated polyene carboxylic acids, and diversely decorated imidazoles with high functional group compatibility. The presence of a removable pyrimidine directing group and the use of a bidentate phosphine ligand are pivotal to the success of the catalytic reaction. This process is also suitable for benzimidazoles. Importantly, the scalability and diversification of the products highlight the potential of this protocol in practical applications. Detailed exptl. and computational studies provide important insights into the underlying reaction mechanism. In the experiment, the researchers used many compounds, for example, 4-Bromo-1H-benzoimidazole (cas: 83741-35-9Product Details of 83741-35-9).
4-Bromo-1H-benzoimidazole (cas: 83741-35-9) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Product Details of 83741-35-9
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem