Dual Heterogeneous Catalysis for a Regioselective Three- Component Synthesis of Bi- and Tri(hetero)arylpyridines was written by Allais, Christophe;Lieby-Muller, Frederic;Constantieux, Thierry;Rodriguez, Jean. And the article was included in Advanced Synthesis & Catalysis in 2012.HPLC of Formula: 85692-37-1 This article mentions the following:
We have designed a new, user-friendly oxidative dual heterogeneous catalytic system capable of promoting polysubstituted pyridines as unique products from simple activated Michael acceptors, 1,3-dicarbonyls, and ammonium acetate. This metal-free environmentally respectful, and totally regioselective domino reaction proved to be a great strategy to access bi- and triaryl-type pyridines as well as challenging bi- and triheteroaryl-type pyridines in a single operation. E.g., in presence of 4Å mol. sieves, activated carbon, and O2, reaction of PhCH:CHCO2Me and Me acetoacetate gave 91% biarylpyridine (I). In the experiment, the researchers used many compounds, for example, 1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1HPLC of Formula: 85692-37-1).
1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.HPLC of Formula: 85692-37-1
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem