A highly effective sulfamic acid/methanol catalytic system for the synthesis of benzimidazole derivatives at room temperature was written by Zhang, Zhan-Hui;Li, Tong-Shuang;Li, Jian-Jiong. And the article was included in Monatshefte fuer Chemie in 2007.Safety of 7-Methyl-1H-benzo[d]imidazole This article mentions the following:
Sulfamic acid/methanol was an efficient catalytic system for the synthesis of benzimidazole compounds through the condensation of o-phenylenediamines with orthoesters in high yields at room temperature In the experiment, the researchers used many compounds, for example, 7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6Safety of 7-Methyl-1H-benzo[d]imidazole).
7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Safety of 7-Methyl-1H-benzo[d]imidazole
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem