Diastereoselective Trapping of Transient Carboxylic Oxonium Ylides with 伪,尾-Unsaturated 2-Acyl Imidazoles was written by Zhang, Mengchu;Zhang, Tianyuan;Zhang, Dan;Hu, Wenhao. And the article was included in Advanced Synthesis & Catalysis in 2020.Safety of 1-(1-Methyl-1H-imidazol-2-yl)ethanone This article mentions the following:
A diastereoselective reaction of cyclopropene carboxylic acids with 伪,尾-unsaturated 2-acyl imidazoles was developed to report a Michael-type trapping of transient carboxylic oxonium ylides. This transformation provided a direct approach for the construction of valuable 纬-butenolide derivatives I [R1 = Ph, 4-FC6H4, 3,4,5-trimethoxyphenyl, etc.; R2 = Ph, 2-furyl, 4-NCC6H4, etc.] in good yields (60-99%) with high diastereoselectivities (up to >95:5 dr) under mild reaction conditions. In the experiment, the researchers used many compounds, for example, 1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1Safety of 1-(1-Methyl-1H-imidazol-2-yl)ethanone).
1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3鈥揅6) is higher than in water and generally decreases with a Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Safety of 1-(1-Methyl-1H-imidazol-2-yl)ethanone
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem