Efficacy and safety observation of candesartan cilexetil combined with atorvastatin in treatment of hypertension complicated with paroxysmal atrial fibrillation was written by Xue, Chunyan;Quan, Ruidong. And the article was included in Guizhou Yiyao in 2021.Product Details of 145040-37-5 This article mentions the following:
Objective: To investigate the efficacy and safety of candesartan cilexetil combined with atorvastatin in the treatment of hypertension complicated with paroxysmal atrial fibrillation. Methods: In this study, 94 patients with hypertension and paroxysmal atrial fibrillation diagnosed in our hospital were selected as the research objects, and they were randomly divided into the combination group and the routine group, with 47 cases in each group. The combination group was given candesartan cilexetil combined with atorvastatin, and the routine group was given candesartan cilexetil combined with nifedipine. In this study, blood pressure, atrial fibrillation attack, left atrial diameter, and serum levels of brain natriuretic peptide (BNP) and matrix metalloproteinase 2 (MMP-2) were observed before and after treatment. Results: The expression levels of MMP-2 and BNP, as well as the levels of hs-CRP, IL-6 and blood pressure in the combined group were significantly lower than those in the conventional group (P < 0.05). Conclusion: Candesartan cilexetil combined with atorvastatin in the treatment of hypertension complicated with paroxysmal atrial fibrillation could reduce blood pressure and atrial fibrillation episodes, reverse atrial remodeling, and improve inflammatory state. In the experiment, the researchers used many compounds, for example, 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5Product Details of 145040-37-5).
1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Product Details of 145040-37-5
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem