Cu-catalyzed amidation of halogenated imidazoles was written by Wang, Mo;Zhang, Zhenfeng;Xie, Fang;Zhang, Wanbin. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2014.Synthetic Route of C4H5BrN2 This article mentions the following:
An efficient methodol. involving the Cu-catalyzed amidation of halogenated imidazoles has been successfully developed. The amidated product of 5-bromo-1-alkylimidazole was further applied to the synthesis of a new chiral imidazole nucleophilic catalyst for the kinetic resolution of secondary alcs. In the experiment, the researchers used many compounds, for example, 4-Bromo-1-methylimidazole (cas: 25676-75-9Synthetic Route of C4H5BrN2).
4-Bromo-1-methylimidazole (cas: 25676-75-9) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Synthetic Route of C4H5BrN2
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem