DNA vs. Mirror Image DNA: A Universal Approach to Tune the Absolute Configuration in DNA-Based Asymmetric Catalysis was written by Wang, Jocelyn;Benedetti, Erica;Bethge, Lucas;Vonhoff, Stefan;Klussmann, Sven;Vasseur, Jean-Jacques;Cossy, Janine;Smietana, Michael;Arseniyadis, Stellios. And the article was included in Angewandte Chemie, International Edition in 2013.Electric Literature of C6H8N2O This article mentions the following:
In the presence of DNA oligomers containing D-ribose or L-ribose sugar backbones such as 5′-dTCAGGGCCCTGATCAGGGCCCTGA-3′, and (4,4′-dimethyl-2,2′-bipyridine)copper(II) nitrate, alkenoylimidazoles I (R = Me, Ph, 2-BrC6H4, 4-MeOC6H4, 4-ClC6H4, 2-furanyl) underwent enantioselective Friedel-Crafts and addition reactions with N-methylindole, 5-methoxyindole, di-Me malonate, and nitromethane to give addition products such as imidazolyloxopropylmalonates II (R = Ph, 2-BrC6H4, 4-MeOC6H4, 4-ClC6H4, 2-furanyl) in 58-90% ee for Friedel-Crafts reactions and in 67-99% for Michael addition reactions. D-ribose or L-ribose sugar backbone-containing DNA oligomers gave enantiomeric products; the enantioselectivity depended on the DNA sequence, with reactions using the DNA sequence 5′-dCAGTCAGTACTGACTGCAGTCAGTACTGACTG-3′ giving lower enantioselectivities. In the experiment, the researchers used many compounds, for example, 1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1Electric Literature of C6H8N2O).
1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Electric Literature of C6H8N2O
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem