Sarfraz, Ayesha et al. published their research in Journal of Molecular Structure in 2022 | CAS: 21252-69-7

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.SDS of cas: 21252-69-7

Synthesis, In silico and in vitro studies of Silver(I)-N-heterocyclic carbene complexes was written by Sarfraz, Ayesha;Ashraf, Rizwan;Ali, Shaukat;Taskin-Tok, Tugba;Khalid, Zohra;Ullah, Sana;Kahlid, Talha;Mushtaq, Muhammad;El-Bahy, Salah M.;El-Bahy, Zeinhom M.. And the article was included in Journal of Molecular Structure in 2022.SDS of cas: 21252-69-7 This article mentions the following:

In the present study, four silver based NHC (N-heterocyclic carbene) complexes (1c4c) were designed and synthesized from their precursor salts (1b4b). The successful synthesis of salts and complexes was assured through spectroscopic techniques (UV-visible, FTIR, 1H NMR) as well as mass spectrometry. The in silico ADMET study and mol. docking calculations predicted the compounds are good drug candidates having therapeutic potential against multiple cancer targets including COX-1, VEGFA, HIF as well as VGF. Results of in vitro study conducted through MTT assay confirmed that all test compounds have concentration dependent potency but silver complexes (1c4c) have far superior activity than precursor, salts (1b4b) and slightly lower than standard drugs (carboplatin and cisplatin) against various cancer cell lines. Among the studied compounds, 3c showed lowest IC50 value of 0.981 卤 0.09, 1.10 卤 0.14 and 0.973 卤 0.12渭g/mL against MCF-7, HCT-116 and A549 resp. The test compounds were found good antibacterial agents, when screened against bacterial strains (Staphylococcus aureus, Micrococcus luteus, Escherichia coli and S. typhimurium), as well as antioxidant agents when tested against DPPH free radicals. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7SDS of cas: 21252-69-7).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.SDS of cas: 21252-69-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem