Dopaminergic and serotonergic activities of imidazoquinolinones and related compounds was written by Moon, Malcolm W.;Morris, Jeanette K.;Heier, Richard F.;Chidester, Connie G.;Hoffmann, William E.;Piercey, Montford F.;Althaus, John S.;VonVoigtlander, Philip F.;Evans, Dawna L.. And the article was included in Journal of Medicinal Chemistry in 1992.Name: 7-Methyl-1H-benzo[d]imidazole This article mentions the following:
The synthesis of 5-(dipropylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (I), a potent dopamine D2 agonist showing high dopamine/serotonin (5HT1A) selectivity, is described. Dopaminergic activity is associated with the (R)-enantiomer of I; the (S)-enantiomer shows no dopaminergic activity. A series of analogs where the imidazolone ring was modified to various 5- or 6-membered heterocyclic rings were prepared Some of these compounds showed a combination of dopaminergic and serotonergic activity, while one compound, 6-(dipropylamino)-1,2,6,7-tetrahydro-3H,5H-pyrido[3,2,1-ij]quinazolin-3-one (II), was a selective serotonergic agonist. Various analogs of I where the dipropylamine substituent was modified were prepared Most of these showed reduced dopaminergic activity, while several were as potent as I at the serotonin 5HT1A receptor. Orientations for the new compounds at dopamine and serotonin receptors are proposed and compared with those of other tricyclic ligands known to have high affinity at these receptors. In the experiment, the researchers used many compounds, for example, 7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6Name: 7-Methyl-1H-benzo[d]imidazole).
7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Name: 7-Methyl-1H-benzo[d]imidazole
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem