Dynamic conformational and exchange processes in 2-(4′-pyridyl)benzazoles was written by Marzin, Claude;Peek, Michael E.;Elguero, Jose;Figeys, Hubert P.;Defay, Nicole. And the article was included in Heterocycles in 1977.COA of Formula: C9H8N2O This article mentions the following:
The rotational barrier about the C-C bond linking the heterocyclic ring systems in I (X = NH, NMe, NPh, O, S; Q = CH, N; R = Me, H), II, and III (R = H, Me; X = NH, NMe, NPh, O, S) were determined by 1H NMR. The H-exchange reaction in I (Q = CH, X = NH, R = H, Me) was slow enough to be observed in both 13C and 1H NMR as peak broadenings. The conformations of the heterocyclic ring systems are discussed. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4COA of Formula: C9H8N2O).
1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).COA of Formula: C9H8N2O
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem