Amphiphilic multi-charged cyclodextrins and vitamin K co-assembly as a synergistic coagulant was written by Li, Pei-yu;Chen, Yong;Chen, Chang-hui;Liu, Yu. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2019.Computed Properties of C11H20N2 This article mentions the following:
Balancing and neutralizing heparin dosing after surgeries and hemodialysis treatment is of great importance in medical and clin. fields. In this study, a series of new amphiphilic multi-charged cyclodextrins (AMCD)s as anti-heparin coagulants were designed and synthesized. The AMCD assembly was capable of selective heparin binding through multivalent bonding and showed a better neutralizing effect towards both unfractionated heparin and low mol. weight heparin than protamine in plasma. Meanwhile, an AMCD and vitamin K (VK) co-assembly was prepared to realize heparin-responsive VK release and provide a novel VK deficiency treatment for hemodialysis patients. This AMCD-VK co-assembly for heparin neutralization & vitamin K supplementation synergistic coagulation represents a promising candidate as a clin. anti-heparin coagulant. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Computed Properties of C11H20N2).
1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Computed Properties of C11H20N2
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem