Syntheses of 伪,尾-unsaturated ketones starting from vinylic and allylic Grignard reagents via 2-imidazolylmethanol intermediates was written by Hayakawa, Satoshi;Michiue, Toru;Okamoto, Masao;Hatakeyama, Shoko;Ohta, Shunsaku. And the article was included in Heterocycles in 1988.Recommanded Product: 85692-37-1 This article mentions the following:
The title unsaturated ketones, e.g., E-RCOCH:CHR1 [I; R = R1 = Ph; R = Me(CH2)5, Me2C:CHCH2CH2CHMeCH2, R1 = Me] were prepared from acylimidazoles II and R1CH:CHBr (III). Thus, Grignard reaction of II and III gave 92-100% imidazolylmethanols IV. Quaternization of IV with Me2SO4 followed by elimination with K2CO3 gave 87-90% I. Similarly, Grignard reactions of II [R = Me(CH2)5, cyclohexyl, Ph] with R2CH:CHCH2Cl (R2 = H, Me, Ph) gave hydroxyimidazoles V which were cleaved to give RCOCHR2CH:CH2. Acidic isomerization gave RCOCR2:CHMe. This methodol. was used to prepare (卤)-(ar)-turmerone 4-MeC6H4CHMeCH2COCH:CMe2 in 5 steps from II (R = Me), p-MeC6H4CHO, and CH2:CMeCH2Cl. In the experiment, the researchers used many compounds, for example, 1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1Recommanded Product: 85692-37-1).
1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Recommanded Product: 85692-37-1
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem