Halogenated (acylamino)imidazoles and benzimidazoles for directed halogen-metal exchange-based functionalization was written by Groziak, Michael P.;Ding, Hong. And the article was included in Acta Chimica Slovenica in 2000.Electric Literature of C4H5N3O2 This article mentions the following:
Regioselective syntheses of 4- and 5-(acylamino)-1-alkylimidazoles bearing an ortho-halogen atom have been developed. Suitable for use in ortho-directed halogen-metal exchange-mediated ring functionalizations, these compounds are valuable precursors to ortho-functionalized versions of biol. active 4- and 5-aminoimidazoles. To widen the scope of this approach to cover similarly-substituted benzimidazoles and their potentially bioactive nucleosides, the synthesis of halogenated 5- and 6-(acylamino)-benzimidazoles and their ribosides was also explored. In the experiment, the researchers used many compounds, for example, 1-Methyl-4-nitroimidazole (cas: 3034-41-1Electric Literature of C4H5N3O2).
1-Methyl-4-nitroimidazole (cas: 3034-41-1) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Electric Literature of C4H5N3O2
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem