Mechanism of methylation of 4(or 5)-nitroglyoxaline by methyl sulfate was written by Grimison, A.;Ridd, J. H.. And the article was included in Chemistry & Industry (London, United Kingdom) in 1956.Name: 1-Methyl-4-nitroimidazole This article mentions the following:
A kinetic study was undertaken under homogeneous conditions. The acidity of 4(or 5)-nitroglyoxaline (I) in water was determined from UV spectra, pK 9.22 in aqueous 10% EtOH containing 0.3-0.9N NaOH. The rate was k2(Me2SO4) (G–), where G– is the conjugate base of I. The rate of concurrent hydrolysis of Me2SO4 (II) was k’1(Me2SO4) + k’2(Me2SO4) (OH–). At 25掳, k2 = 1.9 脳 10-2; k’2 = 1.6 脳 10-2; k’1 = 1.7 脳 10-1, all in moles 1.-1 sec.-1 Kinetic results point to nucleophilic attack by G– on II, the product being the 1,4-isomer, in contrast to the 1,5-isomer obtained in acidic media, which also causes a different reaction mechanism. In the experiment, the researchers used many compounds, for example, 1-Methyl-4-nitroimidazole (cas: 3034-41-1Name: 1-Methyl-4-nitroimidazole).
1-Methyl-4-nitroimidazole (cas: 3034-41-1) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Name: 1-Methyl-4-nitroimidazole
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem