The ionization constants of some imidazoles was written by Gallo, Gian Gualberto;Pasqualucci, Carmine Renato;Radaelli, Pietro;Lancini, Gian Carlo. And the article was included in Journal of Organic Chemistry in 1964.Application of 3034-41-1 This article mentions the following:
The basic and the acidic ionization constants of some imidazole derivatives have been determined spectrophotometrically or potentiometrically. For the nitroimidazoles, the spectrophotometric method has been used in concentrated sulfuric acid solutions, for which the Hammett acidity function, H0, has been adopted. Tautomeric equilibrium constants of the imidazoles containing an imino H have been calculated The ionization constants have been correlated to the substituents and their position in the imidazole ring. The usefulness of pKa measurements in assigning structures of these compounds is pointed out. In the experiment, the researchers used many compounds, for example, 1-Methyl-4-nitroimidazole (cas: 3034-41-1Application of 3034-41-1).
1-Methyl-4-nitroimidazole (cas: 3034-41-1) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Application of 3034-41-1
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem