A library of novel hydroxamic acids targeting the metallo-protease family: Design, parallel synthesis and screening was written by Flipo, Marion;Beghyn, Terence;Charton, Julie;Leroux, Virginie A.;Deprez, Benoit P.;Deprez-Poulain, Rebecca F.. And the article was included in Bioorganic & Medicinal Chemistry in 2007.Synthetic Route of C9H8N2O This article mentions the following:
The authors report here the design and parallel synthesis of 217 compounds based on a malonic-hydroxamic acid template. These compounds are obtained via a two-step solution-phase procedure. The set of diverse building-blocks used makes this strategy suitable for the search of inhibitors of various metallo-proteases and for the investigation of the biol. role of new metallo-proteases. As a proof of concept, the authors screened this library on neutral aminopeptidase (APN; E.C. 3.4.11.2), the prototypal enzyme of the M1 family. Several submicromolar inhibitors were identified. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4Synthetic Route of C9H8N2O).
1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Synthetic Route of C9H8N2O
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem